This is the web service for generation and modification of the net of xenobiotics metabolism. User could define different parameters of generation.
Value (cut-off) is the probability of metabolite formation is calculated by using integrated assessment of preliminary prediction of biotransformation classes and prediction of site of modification for each of biotransformation classes. For faster and more accurate generation choose cut-off> 0.9
We use GUSAR program for calculation toxicity end-points, which are based on the log10 representation of LD50 values (mg/kg) for rats with intravenous type of administration
